NAD+ 500mg
Compounds used in longevity and anti-senescence research.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular metabolism, redox reactions, and sirtuin/PARP signaling. Injectable NAD+ research concentrates on whether parenteral delivery raises tissue NAD+ pools more efficiently than oral precursor supplementation.
Proposed mechanism
NAD+ is the substrate for sirtuins (SIRT1–7), PARPs, and CD38 — enzymes central to DNA repair, mitochondrial function, and inflammaging biology. NAD+ levels decline with age, and restoring the pool is a major axis of longevity research.
Research highlights
- Available in 500 mg and 1000 mg research vials
- Studied as both NAD+ direct and as NAD+ precursors (NMN, NR)
- Central cofactor for sirtuin and PARP signaling
- One of the most discussed compounds in longevity research
Research protocol notes
Injectable NAD+ research typically reconstitutes large quantities (500 mg+) in proportionally larger BAC-water volumes. Slower delivery is common in research protocols due to documented tolerance endpoints at rapid infusion rates.
Stacking and comparative studies
NAD+ research is frequently paired with mitochondrial-support compounds like MOTS-c and SS-31 in longevity designs.
Handling and storage
Lyophilized powder is stable at ambient shipping temperatures. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 28 days. For long-term storage of unreconstituted vials, freeze at −20 °C and protect from light.
Frequently asked
Why inject NAD+ instead of taking NMN or NR orally?
Research compares parenteral delivery to oral-precursor routes — there is ongoing work on which approach raises tissue NAD+ more efficiently.
What are sirtuins?
A family of NAD+-dependent enzymes (SIRT1–7) central to longevity-axis research.
Why is NAD+ research interesting?
NAD+ levels decline substantially with age, and restoring the pool is a central hypothesis in cellular aging biology.
What is the difference between 500 mg and 1000 mg vials?
Total NAD+ mass — choose based on study duration and concentration requirements.
