Buy KPV — 5 mg Lyophilized Vial
Inflammation-resolution research centred on angiogenic and actin-dynamic pathways.
KPV is the C-terminal tripeptide (Lys-Pro-Val) of α-MSH, isolated and studied for its anti-inflammatory activity independent of MC1R-driven pigmentation effects. It features prominently in gut-inflammation and wound-repair research.
Reconstitution volumes
Volumes of bacteriostatic water required to dissolve each vial at common research concentrations.
| Vial | at 2 mg/mL | at 5 mg/mL | at 10 mg/mL |
|---|---|---|---|
| 5 mg | 2.50 mL | 1 mL | 0.50 mL |
| 10 mg | 5 mL | 2 mL | 1 mL |
Numbers are calculated from the stated vial mass. Verify against the supplier's instructions for your specific research protocol.
Available sizes
Key facts
- C-terminal tripeptide of α-MSH
- Anti-inflammatory without pigmentation effects
- Studied in IBD, colitis, and skin-inflammation models
- Small size confers good stability and bioavailability
Mechanism in the literature
KPV exerts anti-inflammatory effects through mechanisms that include suppression of NF-κB signaling. Unlike the full α-MSH peptide, KPV does not drive pigmentation — making it a "pure" anti-inflammatory research tool in melanocortin-adjacent work.
Often paired with
Buyers viewing KPV typically also consider LL-37, VIP and Testagen. Each is in stock, sealed under nitrogen with a lot-matched CoA.
Research use-cases
- C-terminal tripeptide of α-MSH
- Anti-inflammatory without pigmentation effects
- Studied in IBD, colitis, and skin-inflammation models
- Small size confers good stability and bioavailability
Handling in the lab
Reconstitute under sterile technique with bacteriostatic water. Typical volumes range from 1–3 mL depending on the target working concentration. Swirl gently — do not shake — to avoid peptide shearing.
Stacking and paired-compound work
KPV is sometimes combined with BPC-157 in gut-repair research designs.
Storage and shelf-life
Lyophilized powder is stable at ambient shipping temperatures. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 28 days. For long-term storage of unreconstituted vials, freeze at −20 °C and protect from light.
Frequently asked
How does KPV relate to melanotan compounds?
KPV is the last three residues of α-MSH. Melanotan compounds are engineered analogs of α-MSH. KPV isolates the anti-inflammatory tail without the pigmentation-driving MC1R activity.
What models has KPV been studied in?
Colitis, IBD, dermatitis, and other inflammation-driven research models.
Can it be used orally in research?
Its small size confers reasonable oral bioavailability in research, though injectable routes are also used.
Why not just use α-MSH?
α-MSH drives pigmentation via MC1R — a confounding variable in inflammation research. KPV isolates the anti-inflammatory activity.
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